Clinical Studies on Tadalafil for Female Sexual Health

Indian Generic Brands & 2025 Cost Table
How Does Cialis Work?
Schedule IV? (clarify unscheduled status; Rx mandatory)
The Cialis connection
Comparing Efficacy: Sildenafil vs Tadalafil vs Vardenafil
What Will Happen If A Woman Takes Cialis?
Why Tadalafil Differs from Sildenafil (36-h Half-Life)

Indian Generic Brands & 2025 Cost Table

Cream, add drugs, buy cialis powder such as sildenafil, to the mix. Like the tadalafil in the Libido Lift Rx pill mentioned above, the sildenafil in these two prescription topicals is off-label, but a small study from 2020 found that women who used sildenafil cream reported “clinically significant increases” in arousal versus the results from no cream and placebo cream.9 At the time of this writing, the closest thing to an “instant” female arousal pill is Cake Meds’ Libido Lift Rx, which is a dissolvable prescription tablet containing tadalafil that should work in about 30 minutes and may be effective for up to 36 hours.67 Otherwise, pills tend to take the longest to start working (anywhere from a couple of weeks to a month or so). The FDA-approved pill, Addyi, and OTC supplements have the potential to promote the longest-lasting benefits, however, as they build up and continue to be in your system. If pills don’t interest you, then topicals, such as OMG! Cream and Jolt Gel, or the prescription injection, Vyleesi, could be good alternatives.

Cialis for erectile dysfunction (ED)

These also all work within the hour, but the effects only last a short amount of time. Topicals can be effective for around 20-60 minutes, and Vyleesi content in the body peaks at around one hour before falling again.57 Even with combining Addyi and Vyleesi, there don’t appear to be any known risks of mixing these two approaches together at the time of this writing. If this changes, we’ll update this guide with an appropriate warning. But, for now, it appears safe to use a pill or supplement to promote potential long-term benefits while also using female arousal topicals for an extra, more timely boost. L-Arginine, L-citrulline, and L-carnitine may improve blood flow to the genitalia Zinc and magnesium could help physical arousal in people with deficiencies Capsules are vegan-friendly (corn- and plant-based gelatin) Ingredients should be generally safe for most people 60-day money-back guarantee for new customers Subscribe for 15% off of recurring deliveries Save $5 when you visit Promescent using our links on this page Unsafe for pregnant or breastfeeding individuals and those with corn allergies Dose is six capsules daily (three pills, twice a day) L-arginine may trigger a herpes flare-up Promescent made its name by pioneering delay sprays to help men overcome premature ejaculation, but the company has since greatly expanded its catalog of sexual health products. People seeking a more long-term solution might prefer supplements or Addyi (these options take weeks or months to work, but the potential benefits last longer). While many of the sketchy “instant female arousal” pills on the market are not safe, the products we mention in this guide should be safe for most healthy adults.

Product	Dosage	Quantity + Bonus	Price
Cialis Generic	5mg	360 + 10 Pills	268.08€ 255.31€
Cialis Black	80mg	120 + 8 Pills	264.77€ 252.16€
Cialis Black	80mg	60 + 4 Pills	150.98€ 143.79€
Cialis Super Active	20mg	120 + 16 Pills	382.15€ 363.95€
Cialis Generic	20mg	90 + 6 Pills	154.71€ 147.34€
Cialis Original	20mg	8 Pills	61.70€ 58.76€
Cialis Original	20mg	34 + 2 Pills	183.99€ 175.23€
Cialis Generic	60mg	180 + 10 Pills	313.11€ 298.20€
Cialis Professional	20mg	90 + 2 Pills	241.49€ 229.99€
Cialis Generic	60mg	270 + 10 Pills	443.96€ 422.82€
Cialis Professional	20mg	60 + 2 Pills	183.83€ 175.08€
Cialis Black	80mg	270 + 10 Pills	502.88€ 478.93€
Cialis Soft Tabs	20mg	60 + 4 Pills	159.37€ 151.78€

However, we’d be remiss not to mention a few safety considerations that should be kept in mind, including: Pregnant or nursing individuals would be safest sticking with OTC topicals only, as some ingredients in supplements and prescriptions may harm your baby.

How Does Cialis Work?

L-Carnitine is an amino acid that plays a critical role in energy production — it transports fatty acids to the mitochondria (that “powerhouse of the cell” you likely heard about in science class) to be turned into a form of energy called adenosine triphosphate (ATP).21 This amino acid also shows the potential to improve exercise performance while reducing oxidative stress in response to resistance training.22 This could be why Promescent states that VitaFLUX may be able to help you recover more quickly from injury or exhaustion.

1. Is it safe for a woman to take Cialis every day?

The herbal ingredients in various supplements may interact with certain medications or health conditions, so it’s important to get the all-clear from your doctor before taking them.

The cost of Female Cialis in the UK varies between online and local pharmacies.
It’s essential to verify pharmacy credentials before purchase to avoid counterfeit meds.
Female Cialis might be covered by private health insurance plans in some cases.
It should be used as part of an overall sexual health plan, including communication.
Women with liver or kidney issues should avoid using this medication without professional advice.
Potential side effects diminish over time with proper dosing and monitoring.
Follow-up appointments are recommended to assess the medication's efficacy and safety.
Reliable medical advice is key for safe and effective use of Female Cialis in the UK.

Many of these products increase nitric oxide (NO) production, which can lower blood pressure. Those with cardiovascular concerns or who are on blood pressure medications should consult a doctor to make sure these products are safe to try.63 Products containing L-arginine — such as Jolt Gel, HerSolution Gel, and VitaFLUX — could trigger a herpes flare-up (oral, genital, or both).3 Some libido-support products for women, like HerSolution pills (not the gel), may contain a synthetic form of DHEA, a hormone that acts as a precursor to androgens and estrogens. This ingredient has the potential to interact with a host of medications, increase the risk of certain cancers, lower “good” HDL cholesterol, trigger manic episodes, and more.6 12 At varying times and for many reasons, including the hormonal changes of menopause, women and AFAB individuals may notice that their libido has dropped and their desire for sex is much lower than it used to be.13 Fortunately, there are a few generally safe and effective female arousal products on the market. These products take on a few different forms — supplements, gels or topicals, and prescription medications — each with its own way of working to try and rectify your concerns.

Schedule IV? (clarify unscheduled status; Rx mandatory)

Warnings and precautions

Retailer/Pharmacy	Delivery Options	Price Range (£)	Customer Ratings	Notes
LloydsPharmacy	In-store, online delivery	25-60	4.5/5	Prescriptions required
Boots	Physical & online stores	30-55	4.6/5	Consultation recommended
Express Pharmacy	Discreet delivery	20-50	4.7/5	Regulated UK suppliers
Pharmacy2U	Home delivery	25-60	4.4/5	Online consultation needed

The main goals for these products typically include the following potential benefits: Increasing blood flow to the genitals and relaxing smooth muscle tissue by influencing nitric oxide (NO) production.14 Regulating sex hormones — estrogen and testosterone — which may improve sex drive and other related symptoms.15 16 Balancing neurotransmitters, some of which play a major role in libido and sexual excitement.17 Currently, there are only two FDA-approved treatments for hypoactive sexual desire disorder (HSDD): Addyi, a pill, and Vyleesi, an injection. HSDD is believed to be caused by an imbalance of excitatory and inhibitory neurotransmitters in the brain.

The Cialis connection

Authority statement

User Rating (out of 5)	Comments	Effectiveness Score	Commonly Mentioned Benefits	Cons Mentioned
4.5	Improves intimacy and mood	4.3/5	Increased desire, reliability	Mild headaches, cost
4.0	Easy to take, quick results	4.0/5	Faster arousal	Slight flushing
3.8	Some side effects, but effective	3.8/5	Better blood flow	Dizziness, nausea
4.2	Overall good experience, discreet purchase	4.2/5	Enhanced arousal	Price variability

Tadalafil was FDA-approved in 2003 for erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.64 65 However, healthcare providers can prescribe drugs for unapproved uses based on their judgment that they’re medically appropriate; this is known as “off-label” use.42 The tadalafil in Libido Lift Rx is off-label, but research suggests that phosphodiesterase type 5 (PDE5) inhibitors — like tadalafil, sildenafil, and vardenafil — could be an effective treatment for female sexual dysfunction (FSD).66 Female arousal gels or creams can also help with sexual satisfaction.

It is not a lifestyle drug and should not be used for recreational purposes.
The presence of sexual pain (dyspareunia) may negate any potential benefit.
Telemedicine consultations have increased access to private specialists.
The chemical is stable, but tablets should be kept in their original packaging.
A second opinion is advisable if uncertain about a specialist's recommendation.

While these products can’t affect things like hormone or neurotransmitter balance, some of the ingredients can increase genital blood flow and sensitivity, and others can add additional vaginal lubrication. Like supplements, OTC female arousal topicals often rely on botanical ingredients and amino acids. But prescription topicals, like Cake Meds’ O-Cream Rx and Wisp’s OMG!

Comparing Efficacy: Sildenafil vs Tadalafil vs Vardenafil

Individuals with HSDD may do better with one of the two available FDA-approved prescriptions — Addyi (pill) or Vyleesi (injection). Those looking for an “instant” fix could find that topicals, Cake Meds’ Libido Lift Rx, or Vyleesi are what they need (these work within the hour). People seeking a more long-term solution might prefer supplements or Addyi (these options take weeks or months to work, but the potential benefits last longer). While many of the sketchy “instant female arousal” pills on the market are not safe, the products we mention in this guide should be safe for most healthy adults. However, we’d be remiss not to mention a few safety considerations that should be kept in mind, including: Pregnant or nursing individuals would be safest sticking with OTC topicals only, as some ingredients in supplements and prescriptions may harm your baby.

Can women take Cialis?

The herbal ingredients in various supplements may interact with certain medications or health conditions, so it’s important to get the all-clear from your doctor before taking them. Many of these products increase nitric oxide (NO) production, which can lower blood pressure. Those with cardiovascular concerns or who are on blood pressure medications should consult a doctor to make sure these products are safe to try.63 Products containing L-arginine — such as Jolt Gel, HerSolution Gel, and VitaFLUX — could trigger a herpes flare-up (oral, genital, or both).3 Some libido-support products for women, like HerSolution pills (not the gel), may contain a synthetic form of DHEA, a hormone that acts as a precursor to androgens and estrogens. This ingredient has the potential to interact with a host of medications, increase the risk of certain cancers, lower “good” HDL cholesterol, trigger manic episodes, and more.6 12 At varying times and for many reasons, including the hormonal changes of menopause, women and AFAB individuals may notice that their libido has dropped and their desire for sex is much lower than it used to be.13 Fortunately, there are a few generally safe and effective female arousal products on the market. These products take on a few different forms — supplements, gels or topicals, and prescription medications — each with its own way of working to try and rectify your concerns. Cream, add drugs, buy cialis powder such as sildenafil, to the mix. Like the tadalafil in the Libido Lift Rx pill mentioned above, the sildenafil in these two prescription topicals is off-label, but a small study from 2020 found that women who used sildenafil cream reported “clinically significant increases” in arousal versus the results from no cream and placebo cream.9 At the time of this writing, the closest thing to an “instant” female arousal pill is Cake Meds’ Libido Lift Rx, which is a dissolvable prescription tablet containing tadalafil that should work in about 30 minutes and may be effective for up to 36 hours.67 Otherwise, pills tend to take the longest to start working (anywhere from a couple of weeks to a month or so).

What Will Happen If A Woman Takes Cialis?

Its VitaFLUX supplement is available for men and women (both are the exact same except for label color), but in this guide, we'll focus on what this supplement might do for those with female anatomy. Promescent claims VitaFLUX for Women may help: Aid in faster recovery from injury or exhaustion We’ll investigate the validity of these claims next, but it seems like Promescent intends for VitaFLUX to boost both sexual and overall wellness. This is similar to how Leading Edge Health — the company behind HerSolution — markets its female libido supplements. Before delving into the supplement’s potential efficacy, let’s first take a quick look at the active ingredients in VitaFLUX, which include: Though it has more of them, VitaFLUX isn’t the only product in this guide to use amino acids to support sexual health. For example, both Jolt Gel (a topical) and Hello Cake’s Drive For Her (a supplement) also contain L-arginine.

Drug details

Now, let’s break down how (or if) these ingredients can potentially provide the benefits suggested by Promescent. A systematic review of research studies suggests that L-arginine (along with L-citrulline) can result in greater sexual arousal and satisfaction for pre-, peri-, and postmenopausal women who have HSDD or a related concern. The effective daily dosages that led to promising results within the examined studies were similar to the arginine dose delivered daily by VitaFLUX.10 These positive results are likely due to the fact that L-arginine is a precursor of nitric oxide (NO), which promotes better blood flow throughout the body (including to the genitals). Nitric oxide is also believed to play a major role in the smooth muscle relaxation of sexual arousal.14 Additionally, the increase in blood circulation from nitric oxide’s vasodilation properties can reduce vaginal dryness, as vaginal lubrication is actually ultra-filtered blood.19 L-Citrulline is partially converted to L-arginine, which is then converted to nitric oxide, meaning that this amino acid can also promote NO production.10 Research on L-citrulline for sexual dysfunction usually involves it being used with L-arginine, and most of the research on L-citrulline alone involves men. For example, one study found that 1.5g (1,500mg) of L-citrulline appears to be a safe and effective alternative treatment for mild to moderate erectile dysfunction.20 However, since researchers note that this outcome is likely due to increased NO production, it can be assumed that women may also experience similar benefits from L-citrulline. The FDA-approved pill, Addyi, and OTC supplements have the potential to promote the longest-lasting benefits, however, as they build up and continue to be in your system. If pills don’t interest you, then topicals, such as OMG! Cream and Jolt Gel, or the prescription injection, Vyleesi, could be good alternatives.

The mechanism aims to enhance physiological responsiveness, not psychological desire.
It is generally not prescribed for women solely reporting low libido.
The Genito-Pelvic Pain/Penetration Disorder is not an indicated condition.
A specialist may require tests to rule out hormonal causes before considering it.
Discontinuation should be discussed with a doctor, not done abruptly.

These also all work within the hour, but the effects only last a short amount of time. Topicals can be effective for around 20-60 minutes, and Vyleesi content in the body peaks at around one hour before falling again.57 Even with combining Addyi and Vyleesi, there don’t appear to be any known risks of mixing these two approaches together at the time of this writing. If this changes, we’ll update this guide with an appropriate warning. But, for now, it appears safe to use a pill or supplement to promote potential long-term benefits while also using female arousal topicals for an extra, more timely boost. L-Arginine, L-citrulline, and L-carnitine may improve blood flow to the genitalia Zinc and magnesium could help physical arousal in people with deficiencies Capsules are vegan-friendly (corn- and plant-based gelatin) Ingredients should be generally safe for most people 60-day money-back guarantee for new customers Subscribe for 15% off of recurring deliveries Save $5 when you visit Promescent using our links on this page Unsafe for pregnant or breastfeeding individuals and those with corn allergies Dose is six capsules daily (three pills, twice a day) L-arginine may trigger a herpes flare-up Promescent made its name by pioneering delay sprays to help men overcome premature ejaculation, but the company has since greatly expanded its catalog of sexual health products. Its VitaFLUX supplement is available for men and women (both are the exact same except for label color), but in this guide, we'll focus on what this supplement might do for those with female anatomy. Promescent claims VitaFLUX for Women may help: Aid in faster recovery from injury or exhaustion We’ll investigate the validity of these claims next, but it seems like Promescent intends for VitaFLUX to boost both sexual and overall wellness. This is similar to how Leading Edge Health — the company behind HerSolution — markets its female libido supplements. Before delving into the supplement’s potential efficacy, let’s first take a quick look at the active ingredients in VitaFLUX, which include: Though it has more of them, VitaFLUX isn’t the only product in this guide to use amino acids to support sexual health. For example, both Jolt Gel (a topical) and Hello Cake’s Drive For Her (a supplement) also contain L-arginine.

Why Tadalafil Differs from Sildenafil (36-h Half-Life)

Female libido support supplements often tout being an “all-natural” approach to treating sexual concerns. These supplements generally contain herbal and botanical ingredients, vitamins and minerals, or organic compounds, like amino acids. Some, including HerSolution, may use synthetic forms of hormones, like DHEA and melatonin. The main goals for these products typically include the following potential benefits: Increasing blood flow to the genitals and relaxing smooth muscle tissue by influencing nitric oxide (NO) production.14 Regulating sex hormones — estrogen and testosterone — which may improve sex drive and other related symptoms.15 16 Balancing neurotransmitters, some of which play a major role in libido and sexual excitement.17 Currently, there are only two FDA-approved treatments for hypoactive sexual desire disorder (HSDD): Addyi, a pill, and Vyleesi, an injection. HSDD is believed to be caused by an imbalance of excitatory and inhibitory neurotransmitters in the brain.

Drug forms and strengths: 2.5 mg, 5 mg, 10 mg, 20 mg

But other factors, like satisfaction in a relationship or self-esteem, may also play a role.18 Due to the believed involvement of neurotransmitters, both Addyi and Vyleesi regulate or modify the release of these chemical messengers in different ways — the former on serotonin (and indirectly dopamine and norepinephrine) and the latter on dopamine and norepinephrine alone.18 Another prescription pill option, Cake Meds’ Libido Lift Rx, contains the drug tadalafil (generic Cialis). Tadalafil was FDA-approved in 2003 for erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.64 65 However, healthcare providers can prescribe drugs for unapproved uses based on their judgment that they’re medically appropriate; this is known as “off-label” use.42 The tadalafil in Libido Lift Rx is off-label, but research suggests that phosphodiesterase type 5 (PDE5) inhibitors — like tadalafil, sildenafil, and vardenafil — could be an effective treatment for female sexual dysfunction (FSD).66 Female arousal gels or creams can also help with sexual satisfaction. While these products can’t affect things like hormone or neurotransmitter balance, some of the ingredients can increase genital blood flow and sensitivity, and others can add additional vaginal lubrication. Like supplements, OTC female arousal topicals often rely on botanical ingredients and amino acids. But prescription topicals, like Cake Meds’ O-Cream Rx and Wisp’s OMG! Now, let’s break down how (or if) these ingredients can potentially provide the benefits suggested by Promescent. A systematic review of research studies suggests that L-arginine (along with L-citrulline) can result in greater sexual arousal and satisfaction for pre-, peri-, and postmenopausal women who have HSDD or a related concern. The effective daily dosages that led to promising results within the examined studies were similar to the arginine dose delivered daily by VitaFLUX.10 These positive results are likely due to the fact that L-arginine is a precursor of nitric oxide (NO), which promotes better blood flow throughout the body (including to the genitals). Nitric oxide is also believed to play a major role in the smooth muscle relaxation of sexual arousal.14 Additionally, the increase in blood circulation from nitric oxide’s vasodilation properties can reduce vaginal dryness, as vaginal lubrication is actually ultra-filtered blood.19 L-Citrulline is partially converted to L-arginine, which is then converted to nitric oxide, meaning that this amino acid can also promote NO production.10 Research on L-citrulline for sexual dysfunction usually involves it being used with L-arginine, and most of the research on L-citrulline alone involves men.

Female Cialis is often marketed as an enhancement for women experiencing libido issues.
It is not a hormone therapy but works by increasing blood flow to sensitive areas.
Proper patient education on usage can optimize results and reduce risks.
The medication does not cause psychological arousal directly but facilitates physical response.
It is important to discuss any existing medications with a healthcare professional beforehand.
Some women combine it with pelvic floor exercises for better results.
The legal availability of Female Cialis in the UK depends on prescription and regulation.
Future developments aim to provide more targeted treatments for female sexual dysfunction.

For example, one study found that 1.5g (1,500mg) of L-citrulline appears to be a safe and effective alternative treatment for mild to moderate erectile dysfunction.20 However, since researchers note that this outcome is likely due to increased NO production, it can be assumed that women may also experience similar benefits from L-citrulline. L-Carnitine is an amino acid that plays a critical role in energy production — it transports fatty acids to the mitochondria (that “powerhouse of the cell” you likely heard about in science class) to be turned into a form of energy called adenosine triphosphate (ATP).21 This amino acid also shows the potential to improve exercise performance while reducing oxidative stress in response to resistance training.22 This could be why Promescent states that VitaFLUX may be able to help you recover more quickly from injury or exhaustion.