How Sildenafil Citrate Works in the Body
Grapefruit or grapefruit juice can raise sildenafil levels in your body, which can increase the risk of side effects.
- Sildenafil 50 mg is available by prescription only.
- Store tablets in a cool, dry place away from sunlight.
- Do not use with nitrate medications to prevent risk.
- Seek medical advice if you have heart problems.
- It may interact with other medications like antihypertensives.
- Not recommended for women or children.
- The tablet should be swallowed whole with water.
- Do not crush or chew the tablet.
There are no known interactions between sildenafil and alcohol.
- Sildenafil 50 mg is part of PDE5 inhibitor class.
- It may improve quality of life for men with ED.
- Avoid taking it if you have a recent heart attack.
- Be aware of potential priapism, a rare prolonged erection.
- Use with caution if you have low blood pressure.
- Review all medications with your healthcare provider.
- The medication does not cause dependency.
- Check product labels and consult pharmacists if unsure.
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. In particular, make sure that you discuss if you are using any of the following before taking sildenafil. Tell your healthcare provider about all medicines that you take or have recently taken. This may not be a complete list of medicines that can interact with sildenafil.
- Sildenafil 50 mg may cause flushing and nasal stuffiness.
- Do not use if allergic to sildenafil or similar drugs.
- Patients should discuss health history before use.
- It may take longer to work in some individuals.
- Do not use as a performance enhancer.
- Avoid using other medications without doctor approval.
- Keep a record of any side effects experienced.
- Inform your doctor if you are pregnant or breastfeeding.
If you or someone else has used too much sildenafil, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What to avoid
In the U.S., you can report side effects to the FDA at or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at or by calling 866-234-2345. While less common, the most serious side effects of sildenafil are described below, along with what to do if they happen. Sildenafil may cause allergic reactions, which can be serious. Stop taking sildenafil and get help right away if you have any of the following symptoms of a serious allergic reaction.
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Swelling of the face, lips, mouth, tongue, or throat Itching, skin rash, or pale red bumps on the skin called hives Sildenafil may cause an unwanted erection that is persistent, painful, and that may occur without sexual arousal. Permanent damage to the penis may occur if priapism is not treated quickly. Stop taking sildenafil and get emergency help if you have any of the following symptoms of priapism. Erection lasting for more than four hours Erection that is unrelated to sexual stimulation Sildenafil can cause mild, temporary vision changes such as seeing a blue tint, abnormal colors, blurry vision, or sensitivity to light. Though rare, some people have reported permanent vision loss.
Before taking sildenafil,
Stop taking sildenafil and get help right away if you have sudden vision loss in one or both eyes. Sudden hearing loss has been reported after taking sildenafil. This may occur along with dizziness and ringing in the ears. Stop taking sildenafil and get help right away if you have sudden hearing loss or suddenly have trouble hearing as well as usual. Sildenafil may cause a mild and temporary drop in blood pressure. For this use, sildenafil is used only when needed.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Kamagra Polo | 100mg | 12 Pills | 60.21€ 57.34€ | |
| Viagra Generic | 150mg | 60 + 4 Pills | 111.25€ 105.95€ | |
| Viagra Generic | 25mg | 30 + 4 Pills | 47.97€ 45.69€ | |
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Viagra Generic | 100mg | 180 + 8 Pills | 199.37€ 189.88€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ |
Take it as your healthcare provider recommends, which is usually between 30 minutes to four hours before planned sexual activity.
| Brand Name | Approximate Price per Pack | Availability | Notes |
|---|---|---|---|
| Viagra (Pfizer) | $30-$60 for 4 tablets | Widely available online and pharmacies | Brand-name, prescription required |
| Generic Sildenafil | $10-$20 for 4 tablets | Over-the-counter or prescription | Often more affordable |
| Local pharmacies | Varies | Market dependent | Check quality and authenticity |
| Online vendors | Varies | Ensure pharmacy legitimacy | Beware of counterfeit products |
Do not take double or extra doses.
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This makes it easier to get and keep an erection. For pulmonary arterial hypertension, sildenafil relaxes the blood vessels in the lungs. This lowers blood pressure and reduces strain on the heart. 10 mg/mL powder for oral suspension 20 mg, 25 mg, 50 mg, 100 mg oral tablets Sildenafil is also available in an injectable form that is usually given by a healthcare provider in a hospital or clinic. Sildenafil oral tablets should be stored at room temperature, between 68 F to 77 F (20 C to 25 C).
Revatio for Oral Suspension
It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Sildenafil oral liquid should be stored at room temperature below 86 F (30 C) or in the refrigerator, between 36 F to 46 F (2 C to 8 C). Throw away any remaining liquid 60 days after it has been mixed for you by a pharmacist or healthcare professional. Sildenafil injection is usually given by a healthcare provider in a hospital or clinic. You will not store it at home.
What should I do if I accidentally use too much sildenafil?
The most common side effects of sildenafil are listed below. These side effects may vary depending on the condition that is being treated. Tell your healthcare provider if you have any of these side effects that bother you. Pain in your muscles, back, arms, or legs There may be other side effects of sildenafil that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. For this use, take sildenafil as your healthcare provider recommends, which is usually three times a day. If you miss a dose, take it as soon as you remember.
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You may be at a higher risk if you have certain health conditions or take blood pressure medicines. If you feel faint or dizzy, lie down. Tell your healthcare provider right away if you have any of the following symptoms of low blood pressure. You may be at higher risk for this if you take a blood thinner medicine. Tell your healthcare provider if you get nosebleeds often while taking sildenafil.
Other Medical Problems
If your nosebleed is severe or will not stop after applying pressure, get help right away. People who are allergic to any of the following should not take sildenafil. Any of the ingredients in the specific product dispensed Your pharmacist can tell you all of the ingredients in the specific sildenafil products they stock. Sildenafil should not be taken while you are using certain other medicines. Before taking sildenafil, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
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See the Interactions section for more details. Do not take sildenafil unless sildenafil chewable tablets it has been prescribed to you by a healthcare provider. Do not share sildenafil with other people, even if they have the same condition as you. Keep sildenafil out of the reach of children. If you keep sildenafil oral liquid in a refrigerator, make sure to keep it away from children who also use the refrigerator. If it is almost time for your next dose, skip the missed dose and only take the next dose.
Comparing Side Effects
Tell your healthcare provider if you are or plan to become pregnant. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should take sildenafil while breastfeeding. If you take sildenafil after you eat a high-fat meal, such as a burger and fries, it may take longer to start working. Your healthcare provider may recommend limiting or avoiding grapefruit while taking sildenafil. Ask your healthcare provider if you are unsure what to do after a missed dose.
| Patient Group | Recommended Dosage | Administration Timing | Special Considerations |
|---|---|---|---|
| Adult Men with ED | 50 mg as needed | 30 to 60 minutes before sexual activity | Adjust based on efficacy and tolerability |
| Elderly Patients | Same as adults, starting with lower dose | 50 mg usually appropriate | Monitor for side effects |
| Patients with Liver Impairment | Consult healthcare provider | Dose adjustments may be necessary | Increased risk of side effects |
| Patients on CYP3A4 inhibitors | Lower dose recommended | Due to increased drug levels | e.g., ketoconazole, ritonavir |
This survey is being conducted by the WebMD marketing sciences department.
| Precaution/Contraindication | Explanation | Recommendations |
|---|---|---|
| Use with Nitrates | Can cause severe hypotension | Avoid concomitant use |
| Cardiac conditions | Potential stress on cardiovascular system | Consult healthcare provider |
| Recent Stroke or Heart Attack | Increased risk of adverse events | Medical evaluation required |
| Liver or Kidney Impairment | Altered drug metabolism | Dose adjustments needed |
| Sensitive to Sildenafil | Allergic reactions or hypersensitivity | Discontinue if adverse reactions occur |
50 mg PO ~1 hr before sexual activity; however, may be taken anywhere from 30 min to 4 hr before sexual activity Maximum dosing frequency is once per day Based on effectiveness and toleration, may increase dose to maximum of 100 mg or decrease to 25 mg Indicated for treatment of pulmonary arterial hypertension (PAH) (World Health Organization [WHO] Group I) to improve exercise ability and delay clinical worsening Revatio (PO), Liqrev: 20 mg PO TID; may titrate up to 80 mg TID, if required, based on symptoms and tolerability Revatio (IV): 10 mg IV bolus TID 10-mg IV predicted to provide pharmacologic effect equivalent to 10-mg oral dose Do not exceed recommended PO/IV dose Viagra, VibriqueSevere (eg, cirrhosis): Consider initial dose of 25 mg Severe (eg, cirrhosis): Consider initial dose of 25 mg RevatioMild or moderate (Child-Pugh A or B): No dose adjustment requiredSevere (Child-Pugh C): Not studied Mild or moderate (Child-Pugh A or B): No dose adjustment required Viagra, VibriqueMild or moderate (CrCl 30-80 mL/min): No dose adjustment requiredSevere (CrCl <30 mL/min): Consider initial dose of 25 mg Mild or moderate (CrCl 30-80 mL/min): No dose adjustment required Severe (CrCl <30 mL/min): Consider initial dose of 25 mg RevatioAny severity, including severe (CrCl <30 mL/min): No dose adjustment required Any severity, including severe (CrCl <30 mL/min): No dose adjustment required Indicated in children aged 1-17 years for treatment of pulmonary arterial hypertension (PAH) (WHO Group I) to improve exercise ability and, in pediatric patients too young to perform standard exercise testing, pulmonary hemodynamics thought to underly improvements in exercise 20-45 kg: 20 mg PO TID Maximum dose in pediatric patients not identified Based on experience in adults, dose may be titrated up to 40 mg TID, if required, based on symptoms and tolerability Mild or moderate (Child-Pugh A or B): No dose adjustment required Any severity, including severe (CrCl <30 mL/min): No dose adjustment required ≥65 years: 25 mg PO initially ~1 hr before sexual activity; however, may be taken anywhere from 30 min to 4 hr before sexual activity Maximum dosing frequency is once per day Based on effectiveness and toleration, may increase dose to maximum of 100 mg or decrease to 25 mg Indicated for treatment of pulmonary arterial hypertension (PAH) (World Health Organization [WHO] Group I) to improve exercise ability and delay clinical worsening PO: 20 mg PO TID; may titrate up to 80 mg TID, if required , based on symptoms and tolerability 10-mg IV predicted to provide pharmacologic effect equivalent to 10-mg oral dose Recommended PO/IV dose not to be exceeded Adding Revatio to bosentan does not have any beneficial effect on exercise capacity Clinical trials found no significant difference in response between elderly patients and younger adults; however, cautious dose selection should be considered in elderly because of greater frequency of decreased hepatic, renal, and cardiac function, as well as comorbid conditions and concomitant pharmacotherapy Compared with healthy younger volunteers, healthy elderly volunteers (≥65 years) had reduced clearance of sildenafil, resulting in approximately 84% and 107% higher plasma concentrations of sildenafil and its active N-desmethyl metabolite, respectively atazanaviratazanavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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Sexual activity can put extra strain on your heart, which may be unsafe for people with certain health problems, such as a recent heart attack. Talk to your healthcare provider to see if your heart is strong enough for sex. If you feel chest pain, dizziness, or nausea during sex, stop and contact your healthcare provider right away. Sildenafil does not protect against sexually transmitted infections, including HIV. Sildenafil belongs to a group of medicines, known as phosphodiesterase-5 (PDE-5) inhibitors, which are used to treat erectile dysfunction or pulmonary arterial hypertension.
Pregnancy Categories
You should not take more than one PDE-5 inhibitor medicine. Medicines in this group include avanafil (Stendra), sildenafil (Viagra, Revatio, and others), tadalafil (Cialis and others), and vardenafil (Levitra, Staxyn). Use an accurate measuring device to measure your dose of sildenafil oral liquid. A household spoon is not an accurate measuring device and may cause you to take the wrong dose. Ask your pharmacist to recommend an appropriate measuring device.
Pulmonary hypertension
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if sildenafil is right for you. In particular, make sure that you discuss any of the following. Tell your healthcare provider if you have any of the following. Heart problems, such as heart rhythm problems, chest pain, or heart failure Heart attack, stroke, or heart surgery within the past six months High blood pressure that is still too high despite taking medicines for it Peyronie's disease, or a penis with an abnormal curve or shape An erection lasting longer than four hours A blood disorder, such as sickle cell anemia An inherited eye disease called retinitis pigmentosa Vision loss, or a problem with the nerve between your eyes and brain (optic nerve) Health conditions or factors that raise the risk of optic nerve problems, such as diabetes, high cholesterol, smoking, being older than 50, or having a “crowded disc,” which is something an eye doctor may see in an eye exam Pulmonary veno-occlusive disease, a condition where blood vessels in the lungs are blocked It is not known if or how sildenafil could affect pregnancy or harm an unborn baby.