FULL PRESCRIBING INFORMATION: CONTENTS*

Stop using Liqrev and get emergency medical help if you have sudden vision loss. You should not use Liqrev if you are allergic to sildenafil, or: if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas).

• Contraindications include hypersensitivity to sildenafil.
• Patients with heart conditions should consult a cardiologist before use.
• Sildenafil’s safety profile is well-studied in adults.
• The syrup should not be used with children without medical advice.
• Proper disposal of unused syrup is important to avoid misuse.

Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems.

Dosage of Sildenafil For Oral Suspension

This ensures that each dose contains the correct amount of medication. Yes, Sildenafil 2.5 mg/ml Oral Suspension is a homogeneous mixture. This means that the active ingredient is evenly distributed throughout the liquid medium, ensuring consistent dosing. It's best to follow your healthcare provider's instructions regarding food and medication. Some medications may be absorbed differently when taken with certain foods.

6.2 Postmarketing Experience

If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Side effects may include headache, flushing, upset stomach, abnormal vision, nasal congestion, back pain, muscular pain, or nausea. If any of these effects persist or worsen, tell your doctor promptly. Alcohol may interact with Sildenafil and increase the risk of certain side effects. It's best to discuss this with your healthcare provider. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with nitrate medicine can cause a sudden and serious decrease in blood pressure. To make sure Liqrev is safe for you, tell your doctor if you have ever had: heart problems (chest pain, a heart rhythm disorder, heart attack) retinitis pigmentosa (an inherited condition of the eye) have ever had hearing problems such as ringing in the ears, dizziness, or loss of hearing a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia a physical deformity of the penis (such as Peyronie's disease). Sildenafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking sildenafil, most sildenafil 25mg tablets of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoked or were over 50 years old. It is not clear whether this medicine is the actual cause of vision loss. It is especially important to tell your healthcare provider if you take: Liqrev contains sildenafil, which is the same medicine found in another medicine called Viagra® which is used for the treatment of erectile dysfunction. Do not take Viagra or other PDE-5 inhibitors including avanafil (Stendra), tadalafil (Cialis) or vardenafil (Levitra) during treatment with Liqrev. It is not known if sildenafil is safe and effective in children younger than 1 year of age.

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Tell your doctor if you are pregnant. It is not known whether sildenafil will harm an unborn baby.

WARNINGS AND PRECAUTIONS

This is a condition where the small blood vessels in the fingers and toes become narrowed, leading to decreased blood flow. This can result in the affected areas feeling cold and numb, particularly in response to cold temperatures or stress. Sildenafil 2.5 mg/ml Oral Suspension may also be used to treat priapism, a condition where an erection lasts for more than four hours without sexual stimulation. This can be a serious condition that requires immediate medical attention to prevent long-term damage. Finally, Sildenafil 2.5 mg/ml Oral Suspension can be used to treat Peyronie's Disease, a condition where the penis becomes curved due to the buildup of scar tissue.

Indications and Usage for Sildenafil Oral Suspension

This can cause pain and difficulty with sexual intercourse. If you have any questions about the use of Sildenafil 2.5 mg/ml Oral Suspension for any of these conditions, please do not hesitate to reach out for further information. Sildenafil 2.5 mg/ml Oral Suspension is a liquid dosage form of the medication Sildenafil. The suspension provides a uniform distribution of the medication, ensuring accurate dosing. The liquid medium in the Sildenafil 2.5 mg/ml Oral Suspension serves to uniformly disperse the active ingredient, Sildenafil. However, having pulmonary arterial hypertension (PAH) during pregnancy may cause complications such as heart failure, stroke, or medical problems in both mother and baby. The benefit of treating PAH with Liqrev may outweigh any risks to the baby.

8.5 Geriatric Use

Store this medication at room temperature, away from light and moisture. It's important to discuss all medications with your healthcare provider if you are pregnant or breastfeeding. They will be able to advise you on the safest course of action. Sildenafil for oral suspension is a medication used to treat erectile dysfunction (ED) in men in Canada, the US, or other countries. It contains the active ingredient Sildenafil Citrate, a phosphodiesterase type 5 (PDE5) inhibitor.

Regional issues

This medication works by relaxing the blood vessels in the penis, allowing more blood to flow into the area and helping men achieve and maintain an erection. Sildenafil for oral suspension is taken orally, typically 30 minutes to 1 hour before sexual activity. It is important to note that sexual stimulation is required for the medication to work and that it should not be taken by men who do not have ED. It is also important to consult a healthcare provider before taking this medication. Sildenafil for oral suspension is manufactured by sildenafil 25 mg tablets Camber Pharmaceuticals INC. It may not be safe to breastfeed while using this medicine.

Precaution/Contraindication	Details	Advice
Nitrate use	Contraindicated with sildenafil	Risk of severe hypotension
Cardiovascular disease risk	Use with caution	Consult cardiologist before use
Liver or kidney impairment	Dose adjustment needed	Monitor liver/kidney function tests
Allergies to sildenafil or excipients	Check ingredients before administration	Discontinue if allergic reactions occur

Take this medicine exactly as it was prescribed for you. Follow all directions on your prescription label and read all medication guides or instruction sheets.

• Sildenafil interacts with alpha-blockers, leading to hypotension.
• The syrup should be measured with a proper dosing device.
• The syrup form is less common and might have inconsistent absorption.
• Researchers are exploring alternative delivery methods like liquids.
• Pharmaceutical companies rarely produce sildenafil syrup commercially.

Shake the bottle for at least 10 seconds before you measure your dose.

What are some side effects that I need to call my doctor about right away?

Avoid direct sunlight and exposure to heat sources. Keep away from moisture, including bathroom storage areas. Store out of reach of children and pets. Discard unused medicine after expiration or doctor’s advice. Generic name: sildenafil Dosage form: Oral suspension (10 mg/mL) Drug class: Agents for pulmonary hypertension The Liqrev brand name has been discontinued in the U.S. Measure your prescribed dose using an oral dosing syringe. Your dose may be changed by your healthcare provider. Do NOT change your dose or stop taking this medicine without talking to your healthcare provider. Liqrev is usually taken three times a day. Usual Adult Liqrev Dose for Pulmonary Hypertension 20 mg orally three times a day Use: Treatment of PAH (WHO Group I) in adults to improve exercise ability and delay clinical worsening.

Parameter	Value	Description	Remarks
Absorption	Rapid, within 30-60 min	Time to peak plasma concentration	最佳服用时间为餐前或空腹
Bioavailability	Approx. 40%	Percentage of dose reaching systemic circulation	影响药效强度
Half-life	4 hours	Time taken to reduce plasma concentration by half	影响药物持续时间
Metabolism	Hepatic (mainly CYP3A4)	Liver enzymes metabolize sildenafil	酒精或药物相互作用可能影响代谢

Liqrev is available as 10 mg/mL oral suspension.

Country	Approval Status	Regulatory Body	Remarks
United States	Approved for pulmonary hypertension, off-label for ED	FDA	Prescription medication
European Union	Approved with similar indications	EMA	Prescription required
India	Approved for ED and pulmonary hypertension	CDSCO	Over the counter in some regions
Canada	Approved, prescription-only	Health Canada	Strict prescribing guidelines

If you miss a dose, take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.

Non-medical use

Liqrev, received FDA approval on April 28, 2023. Do not take Liqrev if you take nitrate medicines either regularly or occasionally, as this can increase your risk of having serious and sudden low blood pressure. Nitrates medicine may include nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Some medicines can cause unwanted or dangerous effects when used with sildenafil. Tell your doctor about all your current medicines, especially riociguat (Adempas). Do not take two doses at one time. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Drinking alcohol with this medicine can cause side effects. Grapefruit may interact with this medicine and lead to unwanted side effects.

This formulation may be used in cases where the risk-benefit profile for a specific pediatric patient is acceptable.

If generic versions of this product have been approved by the FDA, there may be generic equivalents available. Liqrev (sildenafil) suspension is used for pulmonary arterial hypertension (PAH) to improve adult patients' ability to exercise and to delay clinical worsening. Liqrev works by relaxing the muscles in blood vessels so they become wider this lowers blood pressure in the lungs, and it also increases the amount of blood pumped by the heart (cardiac output). Liqrev is a phosphodiesterase-5 (PDE-5) inhibitor that has its effect by blocking the enzyme PDE-5. Liqrev is available as an oral suspension that is taken three times a day. Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor. Get emergency medical help if you have signs of an allergic reaction to this medicine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

If OVERDOSE is suspected:

Sildenafil for oral suspension works by blocking the enzyme phosphodiesterase type 5 (PDE5), which helps relax and widen the blood vessels. In erectile dysfunction, this action increases blood flow to the penis during sexual stimulation, enabling an erection. In pulmonary arterial hypertension (PAH), it lowers blood pressure in the lungs by improving blood flow, easing the heart’s workload and enhancing physical ability. Flushing (warmth, redness in face or neck) The dosage of Sildenafil for oral suspension depends on the condition being treated, age, and medical history. For erectile dysfunction in adults, a typical starting dose is 50 mg, taken about 30 to 60 minutes before sexual activity, not more than once daily.

Allergy warning

For pulmonary arterial hypertension, the dose varies by age and weight and is usually taken three times a day, spaced 4 to 6 hours apart. Always follow your doctor’s specific instructions for safe and effective use. Store at room temperature between 15°C and 30°C. Keep bottle tightly closed when not in use. Do not freeze; protect from extreme cold temperatures. Stop taking Liqrev and get emergency medical help if you have: heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; vision changes or sudden vision loss; or erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis). Call your doctor at once if you have: severe shortness of breath, cough with foamy mucus; ringing in your ears, or sudden hearing loss; swelling in your hands, ankles, or feet; a light-headed feeling, like you might pass out. abnormal vision (blurred vision, changes in color vision) muscle pain, back pain; or upset stomach.