How Sildenafil Citrate Works in the Body
Avoid higher dosing due to a greater risk of mortality in pediatric patients (age 1 to 17 years) treated with high dose sildenafil monotherapy.
- Sildenafil citrate is a medication used primarily for erectile dysfunction.
- It works by relaxing blood vessels to increase blood flow.
- Sildenafil is also prescribed for pulmonary arterial hypertension.
- Common side effects include headache, flushing, and nasal congestion.
- It should be taken 30-60 minutes before sexual activity.
- Alcohol and high-fat meals can reduce its effectiveness.
- Do not take with nitrate medications due to risk of severe hypotension.
0.5 to 1 mg/kg/dose PO every 8 hours.
- Sildenafil is unsuitable for individuals with severe liver disease.
- Patients should avoid alcohol consumption during treatment.
- Some side effects may resolve on their own within hours.
- Persistent side effects should prompt medical consultation.
- The drug does not cure ED but manages symptoms.
- Lifestyle changes can also improve erectile function.
- Follow your healthcare provider’s instructions precisely.
Prior to the release of pediatric pulmonary hypertension guidelines, the generally accepted dose of sildenafil was 0.5 to 2 mg/kg/dose every 6 to 8 hours, with some regimens, particularly those described in earlier reports, administering doses every 4 hours; however, guidelines recommend more conservative dosing based on a greater risk of mortality in pediatric patients (age 1 to 17 years) treated with high dose sildenafil monotherapy, as seen in the STARTS-2 trial. Relevance of this data to the infant population is unclear.
| Property | Description | Value | Units |
|---|---|---|---|
| Molecular Weight | The mass of one mole of sildenafil citrate | 474.58 | g/mol |
| Chemical Formula | Molecular composition | C22H30N6O4S | |
| Solubility | Water solubility | Slightly soluble | at 25°C |
| pH of Solution | Typical pH when dissolved in water | 3.8 - 4.2 | |
| Melting Point | The temperature at which it melts | 196 - 198 | °C |
0.22 to 0.5 mg/kg/dose PO as a single dose 1 hour prior to discontinuing sildenafil citrate tablet iNO or 4 times daily.
- Some users report headaches and dizziness after taking sildenafil.
- A common side effect is facial flushing and nasal congestion.
- Rare side effects include sudden hearing loss or vision loss.
- Priapism requires urgent medical attention to prevent tissue damage.
- Sudden vision loss should be immediately evaluated by a doctor.
- Allergic reactions such as rash, hives, or swelling are possible.
- Discontinue use and seek medical help if serious side effects occur.
None of the 15 patients receiving a single sildenafil dose of 0.3 to 0.5 mg/kg/dose PO 1 hour prior to discontinuation of iNO experienced rebound pulmonary hypertension compared to 10 of 14 patients receiving placebo.
- Contraindications include use with nitrates and recent heart attack.
- Patients with contraindications should avoid sildenafil entirely.
- Visual disturbances including blue-tinted vision may occur.
- Use caution in patients with liver or kidney impairment.
- Sildenafil can interact with certain antibiotics and antifungals.
- Always inform your doctor about other medications you're taking.
- It does not protect against sexually transmitted infections.
In 7 patients receiving sildenafil 0.22 to 0.47 mg/kg/dose PO 4 times daily, mean iNO dose was significantly reduced compared to baseline within 24 hours of sildenafil initiation (12.2 vs.
Other uses for this medicine
You can ask your healthcare provider or pharmacist for information about SILDENAFIL CITRATE TABLETS that is written for health professionals. For more information, go to or call 1-800-438-1985 What are the ingredients in SILDENAFIL CITRATE TABLETS? This Patient Information has been approved by the U.S. Food and Drug Administration. This product's label may have been updated.
Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
For current full prescribing information, please visit Cardura (doxazosin mesylate), and Minipress (prazosin HCl) are registered trademarks of Pfizer Inc. The other brands listed are trademarks of their respective owners and are not trademarks of Pfizer Inc. The makers of these brands are not affiliated with and do not endorse Pfizer Inc or its products. Phosphodiesterase Inhibitors for EDPhosphodiesterase Inhibitors for PAH May be administered without regard to meals. Shake well for at least 10 seconds prior to each administration.Measure dose with an oral dosing syringe or calibrated measuring device.Concentration of the suspension is 10 mg/mL. 29.8 ppm, p = 0.024).
| Contraindication | Explanation | Severity Level | Notes |
|---|---|---|---|
| Nitrates use | Can cause severe hypotension | Critical | Avoid concomitant use |
| Heart conditions | Risk of cardiovascular events | Moderate | Consult healthcare provider |
| Hypotension | Low blood pressure | Moderate | Use with caution |
| Retinal Disorders | Potential for vision impairment | Mild | Seek medical advice |
Guidelines recommend sildenafil use to prevent rebound pulmonary hypertension and facilitate iNO weaning in patients with evidence of increased pulmonary artery pressure upon iNO withdrawal; however, they do not provide specific dosing.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Polo | 100mg | 120 + 6 Pills | 327.15€ 311.57€ | |
| Viagra Generic | 100mg | 10 Pills | 28.91€ 27.53€ | |
| Viagra Generic | 200mg | 30 + 2 Pills | 83.07€ 79.11€ | |
| Viagra Generic | 50mg | 180 + 8 Pills | 158.82€ 151.26€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Viagra Generic | 150mg | 270 + 10 Pills | 326.61€ 311.06€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Kamagra Polo | 100mg | 32 Pills | 125.88€ 119.89€ | |
| Viagra Generic | 50mg | 360 + 10 Pills | 225.33€ 214.60€ | |
| Viagra Generic | 150mg | 60 + 4 Pills | 111.25€ 105.95€ |
Recommended maintenance dosing for pulmonary hypertension is 0.5 to 1 mg/kg/dose PO 3 times daily in persons younger than 1 year, 10 mg PO 3 times daily in persons weighing 20 kg or less, and 20 mg PO 3 times daily in persons weighing more than 20 kg. A double-blind, placebo-controlled, crossover study evaluated sildenafil for symptomatic secondary Raynaud's phenomenon resistant to vasodilatory therapy. Patients (n = 18, 15 were female) were randomly assigned to receive placebo or sildenafil 50 mg PO twice daily for 4 weeks; a washout period of 1 week was used before crossover.
Society and culture
How should I take SILDENAFIL CITRATE TABLETS? Take SILDENAFIL CITRATE TABLETS exactly as your healthcare provider tells you to take it. Your healthcare provider will tell you how much SILDENAFIL CITRATE TABLETS to take and when to take it. Take SILDENAFIL CITRATE TABLETS about 1 hour before sexual activity. You may take SILDENAFIL CITRATE TABLETS between 30 minutes to 4 hours before sexual activity if needed.
Prevention & Wellness
SILDENAFIL CITRATE TABLETS can be taken with or without food. If you take SILDENAFIL CITRATE TABLETS after a high fat meal (such as a cheeseburger and french fries), SILDENAFIL CITRATE TABLETS may take a little longer to start working Do not take SILDENAFIL CITRATE TABLETS more than 1 time a day. If you accidentally take too much SILDENAFIL CITRATE TABLETS, call your doctor or go to the nearest hospital emergency room right away. What are the possible side effects of SILDENAFIL CITRATE TABLETS? SILDENAFIL CITRATE TABLETS can cause serious side effects. The results showed that sildenafil significantly improved microcirculation and symptoms associated with Raynaud's. In patients with chronic digital ulcerations, sildenafil treatment resulted in healing of trophic lesions which reappeared or progressed when sildenafil was stopped.
Adverse effects
Sildenafil injection is available as a ready to use solution; further dilution is not required.Administer as an IV bolus injection. May decrease the dose to 25 mg or increase the dose to 100 mg PO as needed approximately 1 hour before sexual activity. The dose may be taken from 30 minutes to 4 hours before sexual activity. Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions. 25 mg PO as needed approximately 1 hour before anticipated sexual activity.
Report Problems to the Food and Drug Administration
May increase the dose up to 100 mg PO as needed approximately 1 hour before sexual activity. Dose may be titrated as needed based on symptoms and tolerability to a maximum of 80 mg PO 3 times daily. Although dose-response improvement in exercise ability was not observed in short-term clinical trials in adults with pulmonary hypertension, the delay in clinical worsening with long-term use of sildenafil in a clinical trial supports dosing up to a maximum of 80 mg PO 3 times daily. A maximum dose in pediatric patients has not been identified. Based on experience in adults, the dose may be titrated as needed to a maximum of 40 mg PO 3 times daily based on symptoms and tolerability. Ulcerations did not heal while receiving placebo. Sildenafil therapy may be an alternative therapy in patients with Raynaud's resistant to vasodilatory therapy. 50 mg PO every 8 hours starting the day before ascent and continuing for 5 days after reaching the target altitude or until descent is initiated as an alternative to nifedipine.
3. Downsides
Oral suspension (e.g., Liqrev)Storage: Store at room temperature of 20 to 25 degrees C (68 to 77 degrees F). Discard any unused portion after 90 days of opening the bottle.Powder for oral suspension (e.g., Revatio or generic equivalents)):Do not mix with any other medication or additional flavoring agent.Prior to reconstitution, tap the bottle to loosen the powder.Reconstitute with a total of 90 mL of water added in 2 portions. Initially, add 60 mL of water to the bottle and shake vigorously for at least 30 seconds. Add the remaining 30 mL of water and shake vigorously for at least 30 seconds.Remove the cap and press the adaptor for the oral syringe into the neck of the bottle; replace cap.Write an expiration date of 60 days from the date of reconstitution on the bottle label.Storage: Store below 30 degrees C (86 degrees F) or in refrigerator at 2 to 8 degrees C (36 to 46 degrees F). Discard any unused portion after 60 days.
Can Viagra make sex last longer?
Extemporaneous 2.5 mg/mL sildenafil oral suspension:NOTE: Extemporaneously prepared sildenafil sildenafil 60mg oral suspension is not approved by the FDA; an FDA-approved powder for oral suspension is now commercially available.With a mortar and pestle, grind thirty 25-mg sildenafil citrate tablets to a fine powder.In a separate container, mix 1 of the following: 1) 150 mL of Ora-Sweet with 150 mL of Ora-Plus; or 2) 150 mL of Simple Syrup, NF with 150 mL of methylcellulose 1%.Add a small amount of the mixture to the fine powder and mix into a uniform paste. Add geometric amounts of the vehicle to the almost desired volume while mixing. Transfer to a graduated cylinder and adjust to volume while mixing.Place in amber plastic bottles. Shake well before each use.Storage: This suspension is stable for 91 days when stored at 4 and 25 degrees C. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Prophylactic medications should only be considered for individuals with a prior history of high altitude pulmonary edema. Delay use in extremely premature infants until retinal vascularization is established.
Related/similar drugs
an erection that will not go away (priapism). sudden vision loss in one or both eyes. It is uncertain whether PDE5 inhibitors directly cause the vision loss. Stop taking SILDENAFIL CITRATE TABLETS and call your healthcare provider right away if you have sudden vision loss in one or both eyes. If you have these symptoms, stop taking SILDENAFIL CITRATE TABLETS and contact a doctor right away.
Viagra for ED
The most common side effects of SILDENAFIL CITRATE TABLETS are: abnormal vision, such as changes in color vision (such as having a blue color tinge) and blurred vision In addition, heart attack, stroke, irregular heartbeats and death have happened rarely in men taking SILDENAFIL CITRATE TABLETS. Most, but not all, of these men had heart problems before taking SILDENAFIL CITRATE TABLETS. It is not known if SILDENAFIL CITRATE TABLETS caused these problems. These are not all the possible side effects of SILDENAFIL CITRATE TABLETS. For more information, ask your healthcare provider or pharmacist. The pharmacokinetics of sildenafil are highly variable in neonates; careful dose titration and monitoring is recommended. Prior to the release of pediatric pulmonary hypertension guidelines, the generally accepted dose of sildenafil was 0.5 to 2 mg/kg/dose every 6 to 8 hours, with doses ranging up to 3 mg/kg/dose every 6 hours ; however, guidelines recommend more conservative dosing based on a greater risk of mortality in pediatric patients (age 1 to 17 years) treated with high dose sildenafil monotherapy, as seen in the STARTS-2 trial.
At a glance
You may report sildenafil premature ejaculation side effects to FDA at 1-800-FDA-1088. How should I store SILDENAFIL CITRATE TABLETS? Store SILDENAFIL CITRATE TABLETS at room temperature between 68°F to 77°F (20°C to 25°C). Keep SILDENAFIL CITRATE TABLETS and all medicines out of the reach of children. General information about the safe and effective use of SILDENAFIL CITRATE TABLETS.
What are the side effects of sildenafil?
Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use SILDENAFIL CITRATE TABLETS for a condition for which it was not prescribed. Do not give SILDENAFIL CITRATE TABLETS to other people, even if they have the same symptoms that you have. This Patient Information leaflet summarizes the most important information about SILDENAFIL CITRATE TABLETS. If you would like more information, talk with your healthcare provider.